type: position_score
table:
  filename: ENCFF813EXR.tabix.bed.gz
  header_mode: none
  zero_based: true
  format: tabix
  chrom:
    column_index: 0
  pos_begin:
    column_index: 1
  pos_end:
    column_index: 2
scores:
- id: Histone_ChIP-seq_ENCSR458RRZ
  column_index: 3
  type: float
  desc: 'Histone_ChIP-seq ENCSR458RRZ [biosample_summary="Homo sapiens with nonobstructive coronary artery disease; liver tissue male adult (32 years)" and target="H3K27ac"]'
  histogram:
    type: number
    number_of_bins: 100
meta:
  summary: 'Histone_ChIP-seq ENCSR458RRZ [biosample_summary="Homo sapiens with nonobstructive coronary artery disease; liver tissue male adult (32 years)" and target="H3K27ac"]'
  description: '**status**: released


    **biological\_replicates**: Rep 1


    **summary**: male adult (32 years) with nonobstructive coronary artery disease


    **output\_type**: pseudoreplicated peaks


    **audit\_internal\_action**: Archived analysis {ENCAN670HWC|/analyses/ENCAN670HWC/}
    has in progress subobject quality standard {encode3-histone-chip|/quality-standards/encode3-histone-chip/}


    **audit\_not\_compliant**: NRF (Non Redundant Fraction) is equal to the result
    of the division of the number of reads after duplicates removal by the total number
    of reads. An NRF value in the range 0 - 0.5 is poor complexity, 0.5 - 0.8 is moderate
    complexity, and > 0.8 high complexity. NRF value > 0.8 is recommended, but > 0.5
    is acceptable. ENCODE processed alignments file {ENCFF572NBX|/files/ENCFF572NBX/}
    processed by ChIP-seq ENCODE3 GRCh38 pipeline was generated from a library with
    NRF value of 0.32.


    **audit\_warning**: PBC1 (PCR Bottlenecking Coefficient 1, M1/M\_distinct) is
    the ratio of the number of genomic locations where exactly one read maps uniquely
    (M1) to the number of genomic locations where some reads map (M\_distinct). A
    PBC1 value in the range 0 - 0.5 is severe bottlenecking, 0.5 - 0.8 is moderate
    bottlenecking, 0.8 - 0.9 is mild bottlenecking, and > 0.9 is no bottlenecking.
    PBC1 value > 0.9 is recommended, but > 0.8 is acceptable. ENCODE processed alignments
    file {ENCFF572NBX|/files/ENCFF572NBX/} processed by ChIP-seq ENCODE3 GRCh38 pipeline
    was generated from a library with PBC1 value of 0.53.


    **audit\_warning**: PBC2 (PCR Bottlenecking Coefficient 2, M1/M2) is the ratio
    of the number of genomic locations where exactly one read maps uniquely (M1) to
    the number of genomic locations where two reads map uniquely (M2). A PBC2 value
    in the range 0 - 1 is severe bottlenecking, 1 - 3 is moderate bottlenecking, 3
    - 10 is mild bottlenecking, > 10 is no bottlenecking. PBC2 value > 10 is recommended,
    but > 3 is acceptable. ENCODE processed alignments file {ENCFF572NBX|/files/ENCFF572NBX/}
    processed by ChIP-seq ENCODE3 GRCh38 pipeline was generated from a library with
    PBC2 value of 2.79.'
  labels:
    reference_genome: hg38/genomes/GRCh38-hg38
    accession: ENCSR458RRZ
    status: released
    assay_term_name: ChIP-seq
    simple_biosample_summary: male adult (32 years) with nonobstructive coronary artery
      disease
    biosample_summary: Homo sapiens with nonobstructive coronary artery disease; liver
      tissue male adult (32 years)
    replication_type: unreplicated
    biosample_ontology: /biosample-types/tissue_UBERON_0002107/
    perturbed: false
    doi: 10.17989/ENCSR458RRZ
    date_created: '2015-10-01T07:16:42.057689+00:00'
    date_released: '2013-07-31'
    submitter_comment: It was discovered that the Biosample used in this experiment
      was mislabeled (as left ventricle) during submission to the Roadmap EDACC. In
      October 2018, the ENCODE portal metadata for this experiment and ENCBS360QRF
      were updated to liver. The donor metadata was confirmed and has not changed.
      The data were reprocessed in January 2018 with the liver control.
    target: H3K27ac