type: position_score
table:
  filename: ENCFF691RHT.tabix.bed.gz
  header_mode: none
  zero_based: true
  format: tabix
  chrom:
    column_index: 0
  pos_begin:
    column_index: 1
  pos_end:
    column_index: 2
scores:
- id: DNase-seq_ENCSR775KLH
  column_index: 3
  type: float
  desc: signal
  histogram:
    type: number
    number_of_bins: 100
meta:
  summary: 'DNase-seq ENCSR775KLH [TISSUE: Homo sapiens with Alzheimer''s disease;
    head of caudate nucleus tissue male adult (87 years)]'
  description: '**status**: released


    **biological\_replicates**: Rep 1


    **summary**: male adult (87 years) with Alzheimer''s disease


    **output\_type**: peaks


    **audit\_warning**: Signal Portion of Tags (SPOT) is a measure of enrichment,
    analogous to the commonly used fraction of reads in peaks metric. ENCODE processed
    alignment files {ENCFF706MJM|/files/ENCFF706MJM/} processed by DNase-seq ENCODE4
    v3.0.0 GRCh38 pipeline ({ENCPL848KLD|/pipelines/ENCPL848KLD/}) for GRCh38 assembly  have
    a SPOT1 score of 0.39. According to ENCODE standards, SPOT1 score of 0.4 or higher
    is considered a product of high quality data. Any sample with a SPOT1 score <0.3
    should be targeted for replacement with a higher quality sample, and a SPOT1 score
    of 0.25 is considered minimally acceptable SPOT1 score of 0.25 is considered minimally
    acceptable for rare and hard to find primary tissues. (See {ENCODE DNase-seq data
    standards|/data-standards/dnase-seq-encode4/})'
  labels:
    reference_genome: hg38/genomes/GRCh38-hg38
    accession: ENCSR775KLH
    status: released
    assay_term_name: DNase-seq
    simple_biosample_summary: male adult (87 years) with Alzheimer's disease
    biosample_summary: Homo sapiens with Alzheimer's disease; head of caudate nucleus
      tissue male adult (87 years)
    replication_type: unreplicated
    biosample_ontology: /biosample-types/tissue_UBERON_0002626/
    perturbed: false
    doi: 10.17989/ENCSR775KLH
    date_created: '2020-12-15T22:21:54.001744+00:00'
    date_released: '2021-01-11'
    submitter_comment: ''